AI powered image analysis

Aiforia use cases by application

Over 400 different AI models have been created with Aiforia Create so far, for a multitude of image types (IF, WSI, etc.) and a huge range of therapy areas, research fields, and industrial applications!

Explore some of these examples below!

mHtt aggregation

Huntington's Disease

Implementing AI models to analyze mutant huntingtin (mHtt) aggregation in Huntington's Disease affected brain tissue at the University of Helsinki.

Huntington_before Huntington_after

TH+ neuron quantification

Parkinson’s disease

Automated dopaminergic neuron quantification in Parkinson’s disease research at Duke University.

dopamine_neuron_PD_before dopamine_neuron_PD_after

Amyloid-β detection

Alzheimer’s disease & cerebral amyloid angiopathy

AI-assisted identification of the most characteristic markers of AD and CAA, including Aβ plaques, at Massachusetts General Hospital.

amyloid-β_before amyloid-β_after

Neuron quantification

Parkinson's Disease

Automated neuron quantification for preclinical Parkinson's disease studies at Sanofi.

dopamine_neuron_before dopamine_neuron_after

Iron deposit measurement

Alzheimer's Disease

Measuring the quantity and distribution of iron deposits in grey and white matter in Alzheimer's disease studies at Massachusetts General Hospital.

iron_detection_before iron_detection_after

Astrocyte detection

Parkinson's Disease

Use of AI for image analysis and astrocyte detection in Parkinson’s Disease research at Vall d'Hebron Instituto de Investigación.

astrocytes_PD_before astrocytes_PD_after

α-synuclein assessment

Parkinson's Disease

Quantitative assessment of alpha-synuclein pathology in preclinical Parkinson's disease studies at Lundbeck pharmaceutical company.

alpha-synuclein_before alpha-synuclein_after

TH+ neuron quantification

AI models for the identification and quantification of dopaminergic cells (TH+) in the substantia nigra pars compacta (SNc) at the University of Navarra.

TH+_before TH+_after

Astrocyte reactivity quantification

Quantifying astrocyte reactivity in preclinical neurotoxicity studies at Orion pharmaceutical company. 

astrocytes_orion_before astrocytes_orion_after

Neuron detection

Multichannel Immunofluoresence: somatic and nuclear detection.

multichannel_IF_before multichannel_IF_after

Nerve classification

Classification of nerve components, such as myelin, axon, and nerve fibre.

nerve_myelin-axon-fiber_before nerve_myelin-axon-fiber_after

Cerebellum classification

Automated classification of molecular and purkinje layers in brain image with area measurements. Subsequent detection and count of interneurons and purkinje cells.

brain_cell_classification_before brain_cell_classification_after

Whole slide human brain segmentation

Grey/White matter segmentation and Neuron/Glia counts in human brain sample.

glia_neuron_human_before glia_neuron_human_after

Motoneuron detection

Detection of motoneurons in rat biopsy.

motoneuron_rat_before motoneuron_rat_after

Nigra area detection

Automated nigra area detection.

nigra_detection_before nigra_detection_after

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PD-L1 scoring

Lung Cancer

Automated calculation and scoring of PD-L1 markers in a lung at Leiden University Medical Centre.

Lung-PDL1_before Lung-PDL1_after

Ki-67 quantification

Lung Cancer

Calculating Ki-67 proliferation index for pulmonary carcinoid tumors with AI at the Helsinki University Hospital.

Ki-67 quantification

Tumor outcome prediction

Ovarian cancer

Creation of AI model to accurately classify high grade serous carcinoma into outcome groups at the University of Helsinki.

Ovarian-tumor_before Ovarian-tumor_after

Carcinoma segmentation

Colorectal Cancer

AI-assisted segmentation of colorectal carcinoma digitized images to identify prognostic and predictive histologic signatures at Mayo Clinic.

colorectal-cancer_before colorectal-cancer_after

HER2+ marker detection

Breast Cancer

AI assisted detection of IHC stained CD3+ T-cells, CD20+ B-cells, DC-Lamp+ mature dendritic cells, and Hematoxylin in a HER2+ breast cancer surgical resection at the Royal College of Surgeons in Ireland.

Breast cancer_T, B-cells, dendritic cells_before Breast cancer_T, B-cells, dendritic cells_after

Blast cell and RBC identification

Leukemia

AI trained to identify blast cells and red blood cells on previously diagnosed cases of acute myelogenous leukemia at the Jinnah Sindh Medical University.

blast_cell_before blast_cell_after

Tumor grading

NSCLC

Automating tumor grading in non-small cell lung cancer (NSCLC) studies at MIT.

Tumor_grading_MIT_before Tumor_grading_MIT_after

Tumor grading

Prostate Cancer

Automated tumor grading in prostate cancer biopsies at the Helsinki University Hospital, Finland, and in Region Skåne lab, Sweden.

prostate_grading_before prostate_grading_after

Tumor grading

Breast Cancer

Automated tumor grading in breast cancer biopsies.

Breast cancer_grading_before Breast cancer_grading_after

Mitosis

Mitosis detection and quantification.

Mitosis_before Mitosis_after

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Biomarker identification

PSC

Identifying novel prognostic biomarkers in primary sclerosing cholangitis (PSC) at the Helsinki University Hospital.

PSC_before PSC_after

Ballooning assessment

NAFLD and NASH

AI in studying nonalcoholic fatty liver disease (NAFLD) and its capability to segment structures in liver histology at the University of Helsinki.

ballooning_before ballooning_after

Fibrosis quantification

NAFLD and NASH

Automated quantification of damage and scarring in liver tissue in nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH).

fibrosis_before fibrosis_after

Inflammation quantification

NAFLD and NASH

Automated quantification of inflammation in liver tissue in nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH).

inflammation_before inflammation_after

Steatosis quantification

NAFLD and NASH

Automated quantification of fat accumulation in liver tissue in nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH).

fat-accumulation_before fat-accumulation_after

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Hematopoietic cell enumeration

Bone marrow

AI model used to identify and enumerate hematopoietic cells to determine changes in bone marrow cellularity for pharmacologic safety studies at Charles River Laboratories.

bone_marrow_before bone_marrow_after

Histopathological lesion evaluation

Kidney tissue

Using AI for detecting the cortex and medulla and reviewing tissues for histopathological lesions in blinded studies at Texas A&M University.

kidney_cortex_medulla_before kidney_cortex_medulla_after

DSS Colitis assessment

Colon tissue

DSS-induced colitis AI model trained for histopathological lesion detection and colon inflammation assessments at Charles River Laboratories.

DSS_colitis_before DSS_colitis_after

Malaria detection

Blood smear

Automated malaria parasite detection from blood smears at the University of Helsinki.

malaria_RBC_before malaria_RBC_after

Tuberculosis quantification

Lung tissue

Automated detection and quantification of cells and lesions in tuberculosis studies at Tufts University.

tuberculosis_before tuberculosis_after

Pulmonary fibrosis quantification

Lung tissue

Identification and quantification of histopathological features of idiopathic pulmonary fibrosis (IPF) including fibroblast foci, and interstitial and alveolar inflammatory cells at the University of Helsinki.

lung_fibroblast_lymphocytes_before lung_fibroblast_lymphocytes_after

Neovascular lesion scanning

ocular models

Neovascular lesion identification in SD-OCT scans for preclinical model development with the contract research organization Experimentica.

eye_experimentica_before eye_experimentica_after

Coronavirus identification

Blood & skin samples

Analyzing microscopic images of human blood and tissue to identify patterns of COVID-related disease at the Foundation for the Study of Inflammatory Disease.

coronavirus_before coronavirus_after

Pulmonary fibrosis identification

Lung tissue

Charles River Laboratories pathologists are enhancing image analysis in pre-clinical toxicology, lung studies for lung tissue detection, parenchyma, structural collagen, and fibrotic lesions.

lung_fibrosis_before lung_fibrosis_after

Preeclampsia assessment

Placental tissue

Quantification of HLA-G/CK7 ratios for protein expression in preeclampsia research at Helsinki University Hospital.

preeclampsia_before preeclampsia_after

Epithelium segmentation

Endometrium

Automated segmentation and quantification of endometrial leukocytes and proliferation in PCOS with immunohistochemically stained endometrial samples.

endometrium_epith+stroma_before endometrium_epith+stroma_after

Estrus cycle evaluation

Vaginal smear

AI-assisted image analysis of cytological samples from mice to determine the stages of the estrus cycle at the University of Turku.

estrus_before estrus_after

Follicle quantification

Ovarian follicles
Preclinical studies on identification and quantification of the different stages of ovarian follicles in rats using AI models at Charles River Laboratories.
ovarian_follicles_before ovarian_follicles_after

Immune cell detection

Colon tissue

Multichannel (Immunofluorescence) human colon tissue showing staining for various vascular and immune cell markers in addition to epithelium.

Immune Cells in Human Colon

NICD1 marker annotation

Colon tissue

Aiforia Create training window showing annotations for NICD1 protein in multi-channel (Immunofluorescence) human colon tissue, stained with various vascular & immune cell markers in addition to epithelium.

Human Colon Multichannel 1

Dermis and epidermis detection

Skin

Automated detection of dermis and epidermis of skin tissue sample.

skin_before skin_after

WBC quantification

Blood smear

Automated white blood cell (WBC) count in a blood samples.

WBC_before WBC_after

ARDS identification

Lung tissue

Acute respiratory distress syndrome (ARDS) lesion segmentation and cell identification.

respiratory_disease_before respiratory_disease_after

Cell detection

Yeast sample

Automated detection of intact yeast cells in bright field images.

yeast_cells_before yeast_cells_after

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Yeast contaminants

AI-aided identification of contamination in yeast fermentations.

yeast_lallemand_before yeast_lallemand_after

Salmon skin

Scientists at Nofima used AI to recognize and analyze the successive tissues in Atlantic salmon skin for food safety studies.

fish_before fish_after

Barley

Whole image instance segmentation of barley, including identification of protein matrix, starch, and cell wall. 

barley_before barley_after

Concrete

Measuring concrete porosity and composition.

Concrete AI detection

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