On-demand webinar PD-L1 on the edge: cut-offs, cognitive bias & the case for AI in lung cancer pathology

PD-L1 TPS is simple in theory—but far more complex in practice. When eligibility for life-changing immunotherapy hinges on a 1% or 50% score, even a 5% margin of error can shift a patient’s path entirely.

This webinar takes you inside the real-world diagnostic pressure points of PD-L1 TPS testing in NSCLC. With insights drawn from clinical research, pathology practice, and oncology decision-making, we examine the human limits of PD-L1 scoring and how AI can sharpen clinical decisions. 

What you’ll learn:

  • The 1% that changes everything
    Understand how small differences in PD-L1 Tumor Proportion Score (TPS) drastically influence therapy eligibility—and why that’s a clinical pain point.

  • Cut-offs, callouts, and clinical consequences
    Explore why the 1% and 50% cut-offs carry outsized impact, and how subtle inconsistencies in interpretation can create major therapeutic divergence.

  • The human factor: why pathologists disagree
    Dive into the technical, visual, and psychological reasons manual scoring is prone to variability—especially in borderline cases.

  • Under-called. Over-called. Mis-called.
    See how PD-L1 is commonly misestimated in either direction, and how this leads to patient under-treatment or over-treatment.

  • AI to the assist: can algorithms outscore the experts?
    Unpack the evidence on how AI is being trained to assist PD-L1 scoring—offering reproducibility, speed, and support in tough calls.

  • Bridging the diagnostic divide
    Hear how pathologists and oncologists view PD-L1 differently—and how AI and digital tools may help unify decision-making.

Who should watch?

  • Pathologists involved in biomarker testing
  • Oncologists relying on PD-L1 scores for treatment planning
  • Anyone involved in lung cancer diagnostics or therapeutic decision-making

Richard Doughty__portrait_500x500px

Richard Doughty Medical Director, Aiforia Technologies

Rute P_portrait_500x500px

Rute Pedrosa Senior Field Application Scientist, Aiforia Technologies

Watch the on-demand webinar

On-demand webinar

PD-L1 on the edge: cut-offs, cognitive bias & the case for AI in lung cancer pathology

Intro to Aiforia
00:57
Dr. Doughty's presentation
04:42
Q&A
44:23