News and reflections from the world of AI

Validation of PD-L1 AI model launches in six labs across the Netherlands

Introduction  Programmed death-ligand 1 (PDL1) is a protein that, when attached to T cells, prevent the immune system from killing cancer cells. Hence, PDL1 is used as a biomarker for tumor immune escape, a sign of increasing cancer progression. PDL1 percentage is also a significant predictor for immunotherapy efficacy, whereby immune checkpoint inhibitors bind to PDL1 and block its ability to ...

Interview with Dr. Rish Pai on using AI to study colorectal cancer

Introduction Colorectal cancer is the third most common cancer in the United States and pathologists are becoming increasingly valuable in the management of these patients. Analysis of histological features of the tumors is the main source of data for diagnosis, but there are many components to this. Routine pathologic assessment does not capture a quantitative view of the extensive variability ...

The impact of digital pathology on immuno-oncology

Immuno-oncology (IO) relies on harnessing our own immune systems in order to develop personalized therapies and medications for cancer. For this, a deep understanding of the immune system as well as its role in the regulation of the tumor microenvironment (TME) is pivotal.