Aiforia® Lung Cancer Suite

AI for lung cancer diagnostics

Overcome the challenges of subjective and time-consuming manual PD-L1 scoring in lung cancer – Aiforia® Lung Cancer Suite can reduce errors and help standardize scoring by providing AI-driven PD-L1 assessments that are objective and reproducible. 

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Enhance diagnostic accuracy with AI-driven PD-L1 analysis

PD-L1 is a critical biomarker to guide immunotherapies in lung cancer care, and even minor differences in the analysis of PD-L1 expression can drastically alter treatment plans. Currently, PD-L1 is scored by a pathologist by visual estimation (“eyeballing”), which provides high accuracy in clear-cut cases. Still, it introduces variability of results in the middle ranges of PD-L1 expression with potentially drastic effects in the patient care: Being off by even 5 or 10 percentage points can shift a patient’s treatment regime entirely; under-calling can deny patients effective immunotherapy, while over-calling can lead to unnecessary treatment.

AI assistance brings consistency and efficiency to the PD-L1 scoring: AI algorithms apply the same criteria to every slide, aiming for objective reproducibility. AI can examine every tumor cell across the whole slide (hundreds or thousands), and once trained, AI can score PD-L1 in minutes, accelerating turnaround and freeing pathologists from tedious counting. 

Lung Cancer Suite: AI solution

Aiforia® Lung Cancer PD-L1
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Automatically detects invasive carcinoma and delivers standardized, reproducible tumor proportion scoring (TPS), enhancing diagnostic accuracy and efficiency. It assists pathologists in overcoming the challenges of subjective and time-consuming manual PD-L1 scoring in lung cancer.

Clinical performance highlights
  • Excellent diagnostic accuracy with high correlation to expert visual assessments
  • Enhanced consistency through improved pathologist concordance (Fleiss’ Kappa ~0.87)
  • Significantly streamlined workflow, reducing reporting time by up to 46%
  • Reliable and standardized scoring at critical clinical thresholds (e.g., 1% and 50%)


CE-IVD marked for diagnostic use in EU and EEA countries, and for Research Use Only (RUO) and Performance Studies Only (PSO) in all other market areas

Lung Cancer Suite: AI solution

Aiforia® Lung Cancer PD-L1

Lung_PDL1_20x_1_AImasks_cropped

Automatically detects invasive carcinoma and delivers standardized, reproducible tumor proportion scoring (TPS), enhancing diagnostic accuracy and efficiency. It assists pathologists in overcoming the challenges of subjective and time-consuming manual PD-L1 scoring in lung cancer.

Clinical performance highlights
  • Excellent diagnostic accuracy with high correlation to expert visual assessments
  • Enhanced consistency through improved pathologist concordance (Fleiss’ Kappa ~0.87)
  • Significantly streamlined workflow, reducing reporting time by up to 46%
  • Reliable and standardized scoring at critical clinical thresholds (e.g., 1% and 50%)


CE-IVD marked for diagnostic use in EU and EEA countries, and for Research Use Only (RUO) and Performance Studies Only (PSO) in all other market areas

Why Aiforia® Clinical Suites?

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Precise, transparent AI results

Aiforia takes accuracy beyond standard AI heatmaps by clearly marking the exact tumor areas with detailed visual overlays directly on the digital slides, enabling easy visual confirmation at any magnification level. This approach empowers pathologists with both visual transparency and exact quantitative data, such as accurate tumor area measurements and cell counts, delivering actionable insights.

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Comprehensive case-level review and reporting

Aiforia® Clinical Suites conveniently combine results from multiple AI models, WSIs, and stainings into a case-level view and report for first-read diagnostic support.

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Speeds up each step in your workflow

The AI results are populated directly into the reporting panel. The user can utilize advanced features like case list triaging, pre-ordering of extra stains, and flagging of non-representative samples for a faster workflow.

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Increases the reliability of PD-L1 analysis

Aiforia® Lung Cancer PD-L1 provides standardized scoring, with high accuracy, increasing the reliability of PD-L1 analysis.

Case studies, expert opinions, and more

Resources for lung cancer pathology

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WEBINAR

PD-L1 on the edge: cut-offs, cognitive bias & the case for AI in lung cancer pathology

This webinar takes you inside the real-world diagnostic pressure points of PD-L1 TPS testing in NSCLC.

Watch recording >

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CASE STUDY

Southampton case study: AI-driven analysis of PD-L1 lung cancer

University Hospital Southampton is implementing Aiforia’s clinical PD-L1 lung cancer AI solution to assess PD-L1 staining in lung cancer specimens.

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CASE STUDY

Developing an AI model to determine invasion in pulmonary adenocarcinoma

Dr. Jennifer M. Boland et al. from the Mayo Clinic successfully developed an AI model to determine the invasion in pulmonary adenocarcinoma.

Read more >

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CASE STUDY

Differentiating interstitial lung disease subtypes using AI-based image analysis

Dr. Maxwell L. Smith from Mayo Clinic developed two AI models to detect and quantify histopathologic features in interstitial lung disease (ILD) with the goal of using AI to help differentiate ILD subtypes.

Read the case >

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CASE STUDY

Automating the quantification of PD-L1 in lung cancer

Liesbeth Hondelink, MSc student at Leiden University Medical Centre, describes using AI to automate the quantification of PD-L1 in lung cancer studies.

Read more >

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CASE STUDY

Validation of PD-L1 AI model in six labs in the Netherlands

Labs in the Netherlands are joining together to launch an AI model validation study for PD-L1 scoring with a goal of multi-source domain adaptation.

Read more >

 

CONTACT US

Discover the power of AI for image analysis

Contact us to learn more about how Aiforia’s AI can enhance your diagnostic process and tailor it to your laboratory’s unique needs.

We will help you understand: 

  • How AI-assisted image analysis can increase efficiency, precision, and consistency in the pathology workflow.
  • The limitless possibilities the Aiforia® Platform offers and the suitable solutions for your needs.

Fill in the form, and one of our experts will contact you shortly.